教育背景

Ph.D. Organic Chemistry, Seoul National University, South Korea, 2012.
M.S. Organic Chemistry, Myong Ji University, South Korea, 2006.
B.S. Chemistry, Wuhan University, China, 2004.

工作和研究经历：
2013年4月-至今：1929cc威尼斯, 讲师，硕士生导师

主持课题：
1. 国家自然科学基金青年项目，21402118，半胱氨酸天冬氨酸蛋白酶-1光控分子开关的设计与合成，25万，2015/01-2017/12，已结题
2. 上海市自然科学基金，17ZR1449000，siRNA的分子开关和基因表达的光调控，20万，2017/05-2020/04，已结题
3. 1929cc威尼斯医工交叉基金，Incarvine C调控ROCK抑制肝癌细胞株增殖与血管化拟态形成，2015/01-2017/12，已结题
4. 1929cc威尼斯医工交叉基金，新型SIRT1激活剂E4023改善脂质代谢紊乱的机理研究，2018/01-2020/12，已结题
5. 1929cc威尼斯医工交叉基金，半乳糖凝集素-3调控凝血酶诱导血管钙化的机制研究，2021/01-2023/12，在研
6. 1929cc威尼斯医工交叉基金，负载铂的碳化铌通过清除ROS抑制肝细胞依赖性死亡减轻小鼠缺血再灌注损伤，2022/01-2024/12，在研

药物化学，化学生物学
以活性小分子为工具对生物大分子的功能揭示和调控：
1. 以具有生物活性的小分子为探针，利用化学蛋白质组学，寻找天然产物及合成分子的体内作用靶点和机制。
2. 利用光控分子开关进行生物大分子活性的调控：蛋白质的光控抑制剂，光控小干扰RNA。
3. 基于蛋白质降解靶向嵌合体技术(PROTAC)的蛋白质降解剂的制备和应用。

[14] Zhuojin Yang,# Yi Zheng,# Nafisa Tursumamat, Mingyan Zhu*; Synthesis of 3′-O-Alkyl Homologues and a Biotin Probe of Isorhamnetin and Evaluation of Cytotoxic Efficacy on Cancer Cells. Chem. Biodiv. 2021, 18, e2100301. (IF=2.408)
[13] Zezhong Li, Weixiang Xin, Qing Wang, Mingyan Zhu, Huchen Zhou*; Design and synthesis of N-(3-sulfamoylphenyl)amides as Trypanosoma brucei leucyl-tRNA synthetase inhibitors. Eur. J. Med. Chem. 2021, 217, 113319. (IF=6.514)
[12] Weixiang Xin,# Zezhong Li,# Qing Wang, Jin Du, Mingyan Zhu, Huchen Zhou* Design and synthesis of α-phenoxy-N-sulfonylphenyl acetamides as Trypanosoma brucei Leucyl-tRNA synthetase inhibitors. Eur. J. Med. Chem. 2020, 185, 111827. (IF=5.572)
[11] Zhihua Ge, Zhuojin Yang, Jingshi Liang, Duoling Dong, Mingyan Zhu* Optical Control of GTP Affinity of K-Ras(G12C) by Photoswitchable Inhibitor. ChemBioChem 2019, 20,2916 –2920. (IF=2.774)
[10] Jiong Zhang,# Jinyi Zhang,# Guiyun Hao, Weixiang Xin, Fei Yang, Mingyan Zhu, Huchen Zhou* Design, Synthesis, and Structure-Activity Relationship of 7-Propanamide Benzoxaboroles as Potent Anticancer Agents. J. Med. Chem. 2019, 62(14), 6765–6784. (IF=6.253)
[9] Bo Li, Xiaopeng Hu, Yanzhou Yang, Mingyan Zhu, Jiong Zhang, Yanrong Wang, Xiuying Pei, Huchen Zhou*, Ji Wu* GAS5/miR-21 Axis as a Potential Target to Rescue ZCL-082-Induced Autophagy of Female Germline Stem Cells In Vitro. Mol. Ther. Nucleic Acids 2019, 17, 436-447. (IF=7.032)
[8] Xinyue Li, Xiaopeng Hu, Geng G. Tian, Ping Cheng, Zezhong Li, Mingyan Zhu, Huchen Zhou,* and Ji Wu* C89 Induces Autophagy of Female Germline Stem Cells via Inhibition of the PI3K-Akt Pathway In Vitro. Cells 2019, 8(6), 606 (IF=4.829)
[7] Mingyan Zhu, Huchen Zhou* Azobenzene-based small molecular photoswitches for protein modulation. Org. Biomol. Chem. 2018, 16(44), 8434–8445. (IF=3.423)
[6] Fei Yang, Mingyan Zhu, Jinyi Zhang, Huchen Zhou* Synthesis of biologically active boron-containing compounds. MedChemComm. 2017, 9(2), 201–211. (IF=2.342)
[5] Zhongli Wang, Wenjuan Xie, Mingyan Zhu, Huchen Zhou* Development of a highly reliable assay for ubiquitin-specific protease 2 inhibitors. Bioorg. Med. Chem. Lett. 2017, 27(17), 4015–4018. (IF=2.442)
[4] Jiong Zhang, Fei Yang, Zhitao Qiao, Mingyan Zhu, Huchen Zhou* Chalcone-benzoxaborole hybrids as novel anticancer agents. Bioorg. Med. Chem. Lett., 2016, 26(23), 5797–5801. (IF=2.442)
[3] Jiong Zhang, Mingyan Zhu, Yinan Lin, Huchen Zhou* The synthesis of benzoxaboroles and their applications in medicinal chemistry. Sci. China Chem., 2013, 56(10), 1372–1381. (IF= 4.448)
[2] Mingyan Zhu, Byung Joon Lim, Minseob Koh, Seung Bum Park* Construction of polyheterocyclic benzopyran library with diverse core skeletons through diversity-oriented synthesis pathway: part II. ACS Comb. Sci., 2012, 14(2), 124–134. (IF=3.408)
[1] Mingyan Zhu, Myung Hee Kim, Sanghee Lee, Su Jung Bae, Seong Hwan Kim*, Seung Bum Park* Discovery of novel benzopyranyl tetracycles that act as inhibitors of osteoclastogenesis induced by receptor activator of NF-κB ligand. J. Med. Chem., 2010, 53(24), 8760–8764. (IF=5.207)

<已授权或公开专利>
7. 朱明彦, 郑艺, 乃皮赛·吐逊买买提. 一种异鼠李素光亲和探针及其合成方法和应用. (CN202110743872.7, 已授权，专利号 ZL 2021 1 0743872.7 授权日 2024.5.28)
6. 杨卓进, 朱明彦, 郑艺. 一种异鼠李素生物素探针及其合成方法和应用. (CN112300191A，已授权，专利号 ZL 2020 1 1181060.X 授权日 2022.3.15)
5. 朱明彦, 东多凌, 葛志华, 杨卓进, 梁婧诗. 一种乙酰氨基偶氮苯类衍生物及其制备与应用. (CN109574871A，已授权，专利号 ZL 2018 1 1403987.6 授权日 2022.1.4)
4. Huchen Zhou, Zezhong Li, Jinyi Zhang, Mingyan Zhu. A new type of antitumor compounds: derivatives of 7-propanamide substituted benzoxaborole. (WO2020186504, 已公开，公开日 2020.9.24)
3. Huchen Zhou, Jiong Zhang, Mingyan Zhu, Long Ye, Yiqing Feng. Preparation of 7-propanamide substituted benzoxaboroles and their use as anticancer agents. (WO2019153324A1, 已公开，公开日 2019.8.15)
2. 周虎臣, 张煚, 杨斐, 林轶男, 朱明彦. 一种苯并硼唑7位查尔酮衍生物及其制备与应用. (CN108191898B，已授权，专利号ZL 2017 1 1836291.X 授权日 2020.8.25)
1. 周虎臣, 张煚, 朱明彦, 叶龙, 冯怡卿. 一种苯并硼唑7位脂肪酸的衍生物及其制备与药物用途. (CN107090000B，已授权，专利号ZL 2017 1 0286890.0 授权日 2019.7.12)

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