Xiangdong Xue

xuexd@sjtu.edu.cn

Title / Position

Xiangdong Xue, PhD
Tenure track associate professor, Principal Investigator
Email: xuexd@sjtu.edu.cn
Lab homepage: https://www.x-mol.com/groups/xiangdong_xue
Google Scholar: https://scholar.google.com/citations?user=ksr8ZNsAAAAJ&hl=en
Address:
School of Pharmacy, Shanghai Jiao Tong University
800 Dongchuan Road, Minhang District, Shanghai, China, 200240
Xiangdong Xue, Ph.D., Associate Professor, Principal Investigator at School of Pharmacy, Shanghai Jiao Tong University. Dr. Xue got Ph.D degree from the National Center for Nanoscience and Technology, University of Chinese Academy of Sciences, under the supervision of Professor Xing-Jie Liang. Then, he started his postdoctoral career in the United States. From 2015 to 2020, Dr. Xue worked as a postdoctoral researcher at the Washington University in St. Louis and the University of California, Davis. Then, he joined Shanghai Jiao Tong University as a full-time faculty in December 2020. At present, Dr. Xue has published 46 high-level SCI papers with a total impact factor of over 400, and his papers have been cited more than 2000 times, with an H factor of 24. As the first or corresponding author, Dr. Xue has published 17 papers (total impact factor >180) in some decent journals, such as Nature Nanotechnology, Nature Communications, Advanced Materials, ACS Nano, Biomaterials, Advanced Functional Materials, Advanced Science, Journal of Controlled Release, Nano Research. Dr. Xue has applied 2 PCT international patents and 5 Chinese patents. Meanwhile, Dr. Xue has been recognized by the peers, he has been invited as reviewers of ~20 peer-reviewed journals, including Biomaterials, Advanced Sciences, Small, ACS Applied Material & Interface, Chemical Engineering Journal, Acta Biomaterialia, Journal of Controlled Release, Molecular Pharmaceutics.
Xue lab is newly established, so we are recruiting. Come and join us, we welcome scientists from different fields who are interested in combating cancer with advanced chemical, material, medicinal and biological technologies.

Research fields
o Intelligent small-molecule nanomedicine for cancer treatments
o Precise diagnosis of early-stage cancer with tunable MRI contrast agents and corresponding imaging techniques
o Immunoregulation and immunotherapy for the treatment of advanced metastatic cancer

1. Wang, Z.†; Xue, X.†; Lu, H.; He, Y.; Lu, Z.; Chen, Z.; Yuan, Y.; Tang, N.; Dreyer, C. A.; Quigley, L.; Curro, N.; Lam, K. S.; Walton, J. H.; Lin, T.-y.; Louie, A. Y.; Gilbert, D. A.; Liu, K.; Ferrara, K. W.; Li, Y., Two-way magnetic resonance tuning and enhanced subtraction imaging for non-invasive and quantitative biological imaging. Nature Nanotechnology 2020, 15, 482–490. IF=31.538. https://www.nature.com/articles/s41565-020-0678-5.pdf
2. Xue, X.†; Huang, Y.†; Bo, R.; Jia, B.; Wu, H.; Yuan, Y.; Wang, Z.; Ma, Z.; Jing, D.; Xu, X.; Yu, W.; Lin, T.-y.; Li, Y., Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment. Nature Communications 2018, 9 (1), 3653. IF= 12.121.
https://doi.org/10.1038/s41467-018-06093-5
3. Xue, X.†; Zhao, Y.†; Dai, L.; Zhang, X.; Hao, X.; Zhang, C.; Huo, S.; Liu, J.; Liu, C.; Kumar, A.; Chen, W.-Q.; Zou, G.; Liang, X.-J., Spatiotemporal Drug Release Visualized through a Drug Delivery System with Tunable Aggregation-Induced Emission. Advanced Materials 2014, 26 (5), 712-717. IF= 27.398.
http://onlinelibrary.wiley.com/store/10.1002/adma.201302365/asset/adma201302365.pdf?v=1&t=iz0ldjzy&s=0153d6c3da81f55879576a5138e5f0795f045a2c
4. Xue, X.; Bo, R.; Qu, H.; Jia, B.; Xiao, W.; Yuan, Y.; Vapniarsky, N.; Lindstrom, A.; Wu, H.; Zhang, D.; Li, L.; Ricci, M.; Ma, Z.; Zhu, Z.; Lin, T.-y.; Louie, A. Y.; Li, Y., A nephrotoxicity-free, iron-based contrast agent for magnetic resonance imaging of tumors. Biomaterials 2020, 257, 120234. IF=10.317. http://www.sciencedirect.com/science/article/pii/S0142961220304804
5. Xue, X.†; Huang, Y.†; Wang, X.; Wang, Z.; Carney, R. P.; Li, X.; Yuan, Y.; He, Y.; Lin, T.-y.; Li, Y., Self-indicating, fully active pharmaceutical ingredients nanoparticles (FAPIN) for multimodal imaging guided trimodality cancer therapy. Biomaterials 2018, 161, 203-215. IF=10.317.
http://www.sciencedirect.com/science/article/pii/S0142961218300632
6. Xue, X.†; Jin, S.†; Zhang, C.; Yang, K.; Huo, S.; Chen, F.; Zou, G.; Liang, X.-J., Probe-Inspired Nano-Prodrug with Dual-Color Fluorogenic Property Reveals Spatiotemporal Drug Release in Living Cells. ACS Nano 2015, 9(3), 2729-2739. IF= 14.588. http://pubs.acs.org/doi/pdfplus/10.1021/nn5065452
7. Wang, Z.†; Xue, X.†; He, Y.; Lu, Z.; Jia, B.; Wu, H.; Yuan, Y.; Huang, Y.; Wang, H.; Lu, H.; Lam, K. S.; Lin, T.-Y.; Li, Y., Novel Redox-Responsive Polymeric Magnetosomes with Tunable Magnetic Resonance Property for In Vivo Drug Release Visualization and Dual-Modal Cancer Therapy. Advanced Functional Materials 2018, 1802159. IF=16.836.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.201802159
8. Xue, X.†; Jin, S.†; Li, Z.; Zhang, C.; Guo, W.; Hu, L.; Wang, P. C.; Zhang, J.; Liang, X.-J., Through-Bond Energy Transfer Cassette with Dual-Stokes Shifts for “Double Checked” Cell Imaging. Advanced Science 2017, 1700229. IF=15.840. https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.201700229
9. Yuan, Y.; Bo, R.; Jing, D.; Ma, Z.; Wang, Z.; Lin, T.-y.; Dong, L.; Xue, X.*; Li, Y.*, Excipient-free porphyrin/SN-38 based nanotheranostics for drug delivery and cell imaging. Nano Research 2020, 13, 503-510. IF=8.183.
https://link.springer.com/content/pdf/10.1007/s12274-020-2641-z.pdf
10. Yu, W.†; Xue, X.†; Ma, A.-H.; Ruan, Y.; Zhang, H.; Cheng, F.; Li, Y.; Pan, C.-X.; Lin, T.-Y., Self-Assembled Nanoparticle-Mediated Chemophototherapy Reverses the Drug Resistance of Bladder Cancers through Dual AKT/ERK Inhibition. Advanced Therapeutics 2020, 3, 2000032. IF=N/A.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adtp.202000032
11. Xue, X.†; Ricci, M.†; Qu, H.; Lindstrom, A.; Zhang, D.; Wu, H.; Lin, T.-Y.; Li, Y., Iron-crosslinked Rososome with robust stability and high drug loading for synergistic cancer therapy. Journal of Controlled Release 2020. IF=7.727. http://www.sciencedirect.com/science/article/pii/S0168365920305848
12. Xue, X.; Lindstrom, A.; Qu, H.; Li, Y., Recent advances on small-molecule nanomedicines for cancer treatment. WIREs Nanomedicine and Nanobiotechnology 2019, 12 (3), e1607. IF=7.689.
https://onlinelibrary.wiley.com/doi/abs/10.1002/wnan.1607
13. Xue, X.; Lindstrom, A.; Li, Y., Porphyrin-Based Nanomedicines for Cancer Treatment. Bioconjugate Chemistry 2019, 30 (6), 1585-1603. IF=4.031.
https://doi.org/10.1021/acs.bioconjchem.9b00231
14. Yuan, Y.; He, Y.; Bo, R.; Ma, Z.; Wang, Z.; Dong, L.; Lin, T.-y.; Xue, X.*; Li, Y.*, A facile approach to fabricate self-assembled magnetic nanotheranostics for drug delivery and imaging. Nanoscale 2018, 10 (46), 21634-21639. IF=6.895.
https://pubs.rsc.org/en/content/articlepdf/2018/nr/c8nr05141k
15. Yang, X.†; Xue, X.†; Luo, Y.; Lin, T.-y.; Zhang, H.; Lac, D.; Xiao, K.; He, Y.; Jia, B.; Lam, K. S.; Li, Y., Sub-100nm, long tumor retention SN-38-loaded photonic micelles for tri-modal cancer therapy. Journal of Controlled Release 2017, 261, 297 - 306. IF=7.727.
http://www.sciencedirect.com/science/article/pii/S0168365917307228
16. Xue, X.; Xu, J.; Wang, P. C.; Liang, X.-J., Subcellular behaviour evaluation of nanopharmaceuticals with aggregation-induced emission molecules. Journal of Materials Chemistry C 2016, 4, 2719-2730. IF=7.059.
http://pubs.rsc.org/en/content/articlepdf/2016/tc/c5tc03651h
17. Xue, X. †; Zhao, Y. †; Zhang, X.; Zhang, C.; Kumar, A.; Zhang, X.; Zou, G.; Wang, P.; Zhang, J.; Liang, X.-J., Phenylboronic acid-functionalized magnetic nanoparticles for one-step saccharides enrichment and mass spectrometry analysis. Biophysics Report 2015, 1 (2), 61-70. IF=N/A.

Juan Wei

wwwjuan@sjtu.edu.cn

Title / Position

EDUCATION
Oct. 2011 - Dec. 2014 University of Warwick, Coventry, UK PhD
Sep. 2008 - Mar. 2011 Shanghai Jiao Tong University (SJTU), Shanghai, China MSc
Sep. 2004 - June 2008 Wuhan University (WHU), Wuhan, China BSc

RESEARCH EXPERIENCE
School of Pharmacy, Shanghai Jiaotong University, Shanghai, China
Tenure Track Associate Professor (Nov.2020-now)
Research keywords：Glycomics, glycoproteomics, and glycoprotein drugs

Center for Biomedical Mass Spectrometry, Boston University, Boston, MA
Research Scientist (Jan. 2020– Oct.2020)
Post-doctoral Associate (Feb. 2017– Dec.2019)
Research keywords：Mass spectrometry, glycomics, and glycoproteomics

Biological Sciences, Nanyang Technological University, Singapore
Research scholar (Feb. 2015–Nov. 2015)
Research keywords：Proteomics, protein deamidation, and HILIC/ LERLIC

Analytical and Physical Chemistry, Department of Chemistry, University of Warwick, UK
PhD candidate under the supervision of Professor Peter B. O’Connor in the Ion Cyclotron Resonance Lab (Oct. 2011–Dec. 2014)
Research keywords：FTICR MS, polymer, protein phosphorylation, isotopic fine structure, and electron based tandem mass spectrometry

PUBLICATIONS

1. Wei, J., Tang Y, Ridgeway, M. E., Park, M. A., Costello, C. E., Lin, C. Accurate Identification of Isomeric Glycans by Trapped Ion Mobility Spectrometry-Electronic Excitation Dissociation Tandem Mass Spectrometry Analytical Chemistry, 2020, 92 (19):13211-13220
2. Wei J., Tang Y., Zaia J., Castello C, Lin, C. Variation of Glycosylation Patterns Revealed by PGC-LC- and Gated-TIMS-EED Tandem Mass Spectrometry. FASEB J, 2020, Doi:10.1096/fasebj.2020.34.s1.08858
3. Wei J., Tang Y., Bai, Y., Zaia, J., Costello, C. E., Lin, C. Toward Automatic and Comprehensive Glycan Characterization by Online PGC-LC-EED MS/MS. Analytical Chemistry, 2020, 92(1):782-791
4. Lam, Y .P., Wootton, C. A., Hands-Portman, I., Wei, J., Chiu, C. K., Romero-Canelon, I., Lermyte, F., Barrow, M. P., and O’Connor, P. B. Determination of the Aggregate Binding Site of Amyloid Protofibrils Using Electron Capture Dissociation Tandem Mass Spectrometry. Journal of the American Society for Mass Spectrometry, 2020, 5;31(2):267-276
5. Wei, J., Wu, J., Tang, Y., Ridgeway, M. E., Park, M. A., Costello, C. E., Zaia, J., Lin, C. Characterization and Quantification of Highly Sulfated Glycosaminoglycan Isomers by Gated-TIMS NETD MS/MS. Analytical Chemistry, 2019, 91(4), 2994-3001
6. Wu, J., Wei, J., Hogan, J.D., Boons, G.J., Lin, C. and Zaia, J. Sequencing Heparan Sulfate Using HILIC LC-NETD-MS/MS. Analytical Chemistry, 2019, 91, 18, 11738-11746
7. Lam, Y.P., Wootton, C.A., Hands-Portman, I., Wei, J., Chiu, C.K., Romero-Canelon, I., Lermyte, F., Barrow, M.P. and O’Connor, P.B. Does Deamidation of Islet Amyloid Polypeptide Accelerate Amyloid Fibril Formation? Chemical Communications, 2018, 54(98), 13853-13856
8. Tang, Y.,‡ Wei, J.,‡ Costello, C. E., Lin, C. Characterization of Isomeric Glycans by Reversed Phase Liquid Chromatography-Electronic Excitation Dissociation Tandem Mass Spectrometry. Journal of the American Society for Mass Spectrometry, 2018, 29(6):1295–1307. (共同第一作者)
9. Wu, J., Wei, J., Hogan, J. D., Chopra, P., Joshi, A., Lu, W., Zaia, J. Negative Electron Transfer Dissociation Sequencing of 3-O-Sulfation-Containing Heparan Sulfate Oligosaccharides. Journal of the American Society for Mass Spectrometry, 2018, 29: 1262-1272
10. Khatri, K., Pu, Y., Klein, J. A., Wei, J., Costello, C. E., Lin, C., Zaia, J. Comparison of Collisional and Electron-based Dissociation Modes for Middle-down Analysis of Multiply Glycosylated Peptides. Journal of the American Society for Mass Spectrometry, 2018, 29: 1075-1083
11. Maqueda A. S., Xavier G-P, Wei J., Sze S. K. In-depth Analysis of Glutamine Deamidation by LERLIC-MS/MS in Shotgun Proteomics. Analytical Chemistry, 2016, 88(21): 10573-10582
12. Wei J., Antzutkin O. N., Barrow M. P., Dupree R., Brown S. P., O'Connor P. B. Amyloid Hydrogen Bonding Polymorphism Evaluated by 15N{17O}REAPDOR Solid-state NMR and Ultra-high Resolution FTICR-MS. Biochemistry, 2016, 55(14): 2065-2068
13. van Agthoven M. A., Wootton C. A., Chiron L., Coutouly M. A., Soulby A., Wei J., Barrow M. P., Delsuc M-A, Christian-Rolando C., O’Connor P. B. Two-Dimensional Mass Spectrometry for Proteomics, a Comparative Study with Cytochrome C. Analytical Chemistry, 2016, 88(8): 4409-4417
14. Wei J, O'Connor P. B. Extensive Fragmentation of Pheophytin-a by Infrared Multiphoton Dissociation Tandem Mass Spectrometry. Rapid Communications in Mass Spectrometry, 2015, 29(24): 2411-2418
15. van Agthoven M. A., Barrow M. P., Chiron L., Coutouly M. Wootton C. A., Wei J., A., Soulby A., Delsuc M-A, Christian-Rolando C., O’Connor P. B Differentiating Fragmentation Pathways of Cholesterol by Two-Dimensional Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Journal of the American Society for Mass Spectrometry, 2015, 25: 2105-2114
16. Wei J., Bristow A. W. T., O'Connor P. B. The Competitive Influence of Li+, Na+, K+, Ag+, and H+ on the Fragmentation of a PEGylated Polymeric Excipient. Journal of the American Society for Mass Spectrometry, 2015, 26: 166-173
17. Wei J., Bristow A. W. T., McBride E., Kilgour D. P. A., O'Connor P. B. d-α-tocopheryl Polyethylene Glycol 1000 Succinate: A View from FTICR MS and Tandem MS. Analytical Chemistry, 2014, 86(3):1567-1574
18. Wei J., Li H. L., Barrow M., O’Connor P. B. Structural Characterization of Chlorophyll-a by High Resolution Tandem Mass Spectrometry. Journal of the American Society for Mass Spectrometry, 2013, 24: 753-760
19. Wei J., Gu X., Wang Y., Wu Y, Yan C. Two-dimensional Separation System by on-line Hyphenation of Capillary Isoelectric Focusing with Pressurized Capillary Electrochromatography for Peptide and Protein Mapping. Electrophoresis, 2011, 32(2):230-237
20. Wei J., Gu X., Wang Y., Yan C. Off-line two-dimensional separation system cIEF/pCEC for peptides separation. Chinese Journal of Analytical Chemistry, 2011, 39(2):45-51
21. Mei J., Tian Y. P., He W., Xiao Y. X., Wei J., Feng Y. Q. Preparation approaches of the coated capillaries with liposomes in capillary Electrophoresis. Journal of Chromatography A, 2010, 1217:6979-6986
22. Wu Y., Zhang X. H., Wei J., Xue Y., Bahatibieke M., Wang Y., Yan C. Recent advances and applications of CEC and pCEC. Chinese Journal of Chromatography, 2009, 27(5):609-620

Jin HuiziNatural medicine experiment

Email: kimhz@sjtu.edu.cn
Tel:021-34205989

Title / Position

Researcher

Qiu MingfengDrug development experiment

Email: mfqiu@sjtu.edu.cn
Tel: 021-34204052

Title / Position

Associate Professor

Zhang Baohong Microbiology and Immunology Experiment / Drug Development Experiment

Email: bhzhang@sjtu.edu.cn
Tel：021-34204631

Title / Position

Associate Professor